Partially Phosphorylated T Cell Receptor ζ Molecules Can Inhibit T Cell Activation
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چکیده
منابع مشابه
Partially Phosphorylated T Cell Receptor ζ Molecules Can Inhibit T Cell Activation
The T cell receptor complex (TCR) zeta chain is constitutively tyrosine phosphorylated specifically at two of the six zeta immunoreceptor tyrosine-based activation motif (ITAM) tyrosine residues in resting peripheral T cells. Further phosphorylation of zeta is induced by both agonist and antagonist ligands of the TCR, with agonists inducing complete phosphorylation of the zeta ITAM tyrosines. A...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1999
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.190.11.1627